Indications and medication precautions for Sabril, a Lao version of Lucius
Sabril is an antiepileptic drug primarily used to treat infantile spasms and refractory complex partial seizures. Its use must strictly follow the indications and pay attention to potential risks such as visual impairment and neurotoxicity. Medication for special populations needs to be adjusted individually. The following will provide a detailed introduction to its indications and medication precautions.
1 Indications
Xibaoning is suitable for two situations: monotherapy for infantile spasms (West syndrome) and adjuvant therapy for refractory complex partial epilepsy seizures in adults and children (≥ 10 years old). It should be used under the guidance of a specialist and considered when other treatment options are ineffective.
2 Medication precautions
2.1 Risk of visual impairment
May lead to irreversible peripheral visual field defects, with an incidence rate of about 30% -50%. Baseline ophthalmic examination is required before medication, and visual field should be rechecked every 3-6 months during treatment. If any abnormalities are found, medication should be evaluated and discontinued.
2.2 Neurotoxicity
Common central nervous system adverse reactions such as drowsiness, fatigue, and dizziness. Elderly patients and those with liver and kidney dysfunction are at increased risk and require close monitoring and consideration of dosage adjustments.
2.3 Special populations
Pregnant women should only use it when necessary, and feeding should be suspended during lactation. Children should strictly calculate their dosage according to their weight, and the starting dosage for the elderly should be halved. Individuals with severe liver and kidney dysfunction are prohibited from using it.
2.4 Drug Interactions
Combined use with central nervous system inhibitors may enhance sedative effects. Avoid using it in combination with other medications that can cause visual impairment. Possible decrease in blood concentration of phenytoin, requiring monitoring and adjustment of dosage.
2.5 Precautions for discontinuation of medication
Gradual reduction is necessary to avoid rebound of epileptic seizures. Sudden discontinuation of medication may induce status epilepticus, especially in patients receiving high-dose long-term treatment. The reduction process usually takes 2-4 weeks.
Disclaimer：《Indications and medication precautions for Sabril, a Lao version of Lucius》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！