Side effects, mitigation methods, and storage precautions of Syndax version Revuforj in the United States
Common side effects of remifentanil include abnormalities in the blood, digestive, and metabolic systems, most of which can be alleviated through dosage adjustments or symptomatic treatment.
1. Common side effects and treatment
Adverse reactions with an incidence rate of ≥ 20% include bleeding, nausea, musculoskeletal pain, etc. Digestive symptoms such as nausea can be relieved by taking low-fat meals in portions. Diarrhea should maintain electrolyte balance, and constipation should increase dietary fiber intake.
2 serious reactions that require urgent handling
2.1 Cardiotoxicity
QTc prolongation requires immediate interruption of administration, and should be reduced and restarted after recovery to<500msec. During this period, electrocardiogram and blood potassium levels should be monitored.
2.2 Differentiation syndrome
Manifesting as fever, difficulty breathing, etc., immediate use of glucocorticoids and suspension of remifentanil are required. After symptom control, consider reducing dosage and continuing treatment.
3 dose adjustment strategies
Discontinue treatment for toxicity levels ≥ 3, and gradually reduce dosage after recovery: first to 160mg/m ², second to 95mg/m ², twice daily.
4 Preventive measures
Before administration, it is necessary to control white blood cells to<25Gi/L and regularly monitor electrolytes. Avoid driving when experiencing neurological symptoms.
5 Special Population Management
For those who use strong CYP3A4 inhibitors in combination, the dosage should be adjusted to 160mg twice a day, and for patients weighing less than 40kg, the dosage should be calculated based on body surface area.
6 Special precautions
6.1 Prohibition of refrigeration/freezing
Under no circumstances should remifentanil be placed in a refrigerator freezer or in an environment below 2 ° C, as low temperatures can cause the active ingredient to crystallize and alter the physical and chemical properties of the drug.
6.2 Travel carrying suggestions
Insulated medicine carrying boxes should be used to avoid exposure to high temperature environments such as car trunks. It is recommended to equip temperature recorders for cross time zone transportation.
6.3 Exception Handling
If the drug is exposed to extreme temperatures (<15 ° C or>30 ° C) for more than 24 hours, it should be disposed of and replaced with a new packaging, and cannot be continued to be used.
Disclaimer：《Side effects, mitigation methods, and storage precautions of Syndax version Revuforj in the United States》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！