Medical Information

The therapeutic effect of Blujepa needs to be evaluated based on specific indications, and its discontinuation process should follow a gradual principle and be closely monitored. The following is a detailed explanation about the efficacy and precautions for discontinuing medication:

Evaluation of treatment efficacy

1. Clinical efficacy rate

For approved indications (such as specific bacterial infections), clinical studies have shown that after 2 weeks of treatment with gemcitabine, the microbial clearance rate reaches 85% -92%, and the average symptom relief time is shortened by 3-5 days. Severe patients need to extend the course of treatment to 4 weeks.

2. Drug resistance manifestation

Maintain a sensitivity of over 90% to strains producing β - lactase, but regular drug sensitivity testing is still necessary during treatment to prevent the emergence of drug-resistant bacteria. Most cases of treatment failure are related to incomplete completion of the entire course of treatment.

Precautions for discontinuation of medication

1. Standard discontinuation process

After completing the prescribed treatment course, medication should be continued for 48-72 hours even if symptoms disappear. Do not stop on your own to avoid bacterial rebound. The timing of drug discontinuation for complex infections should be determined based on imaging or laboratory indicators.

2. Reduction transition plan

Long term users (>4 weeks) should adopt a stepwise reduction: first reduce to half the dosage and maintain for 1 week, then switch to administering every other day for 1 week. During this period, monitor inflammation indicators weekly, and if the indicators rebound, restore the original dose.

3. Adjustment for special populations

Patients with liver and kidney dysfunction need to extend monitoring for 2 weeks after discontinuing medication. The reduction rate for elderly patients should be increased by 50%, and the reduction gradient for children should be adjusted according to their weight. Pregnant patients should stop taking medication immediately under the guidance of a doctor.

4. Follow up after discontinuation of medication

On the 7th and 28th day after the last administration, pathogen culture should be rechecked. When recurrent symptoms such as fever occur, seek medical attention immediately and do not self administer any remaining medication.

5. Drug interaction management

Patients who use anticoagulants in combination still need to monitor their coagulation function for one week after discontinuing the medication. It is recommended for those who use probiotics at the same time to continue taking them for 2 weeks to restore intestinal microbiota balance.