Prohibited populations, foods, and restrictions for GSK Blujepa in the UK
Blujepa, as an antibacterial drug, has specific contraindications, dietary restrictions, and medication constraints when used. The following provides detailed explanations from three dimensions: contraindications, dietary taboos, and special restrictions, which must be strictly followed during clinical use.
Contraindicated population
1. Allergic individuals
It is contraindicated for patients allergic to beta lactam antibiotics. Individuals who have previously experienced hypersensitivity reactions such as rash and angioedema should permanently avoid using it.
2. Special physiological state
Pregnant women are prohibited from using it (animal experiments have shown embryotoxicity). Breastfeeding should be suspended during the medication period for lactating women.
3. Organ dysfunction
Patients with severe liver dysfunction (Child Pugh C grade) are contraindicated. Patients with end-stage renal disease (GFR<15mL/min) need to adjust the dosage.
Taboo foods
1. Alcoholic beverages
During the medication period and within 72 hours after discontinuation, alcohol consumption is prohibited as it may trigger disulfiram like reactions (facial flushing, palpitations, etc.).
2. High calcium foods
Milk, cheese and other dairy products should be taken every 2 hours, and calcium ions can significantly reduce drug absorption by 30% -50%.
3. Iron supplements
Iron supplements form chelates with geboda star, and it is recommended to take them 4 hours apart. Anemic patients need to monitor changes in hemoglobin.
Constraints
1. Course control
The routine infection course should not exceed 14 days. Extended use requires weekly monitoring of liver and kidney function to prevent the accumulation of toxicity.
2. Combination therapy
Do not use in combination with potent diuretics as it increases the risk of nephrotoxicity. Combined use with oral contraceptives requires additional contraceptive measures.
3. Special populations
Elderly patients aged 65 and above need to reduce their dosage by 25%. Patients with a history of epilepsy need to monitor changes in electroencephalogram during medication.
Disclaimer：《Prohibited populations, foods, and restrictions for GSK Blujepa in the UK》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！