Side effects and mitigation methods of Acoramidis in Laos
The side effects of Acoramidis mainly include reactions in the cardiovascular and digestive systems, and corresponding relief measures should be taken according to the severity of the symptoms. The following are specific classification of side effects and response plans:
Common side effects and treatment
1. Cardiovascular system response
Possible atrioventricular block or bradycardia may occur. It is recommended to have regular electrocardiogram monitoring. If dizziness or fainting occurs, seek medical attention immediately. Mild symptoms can be relieved by adjusting the administration time.
2. Gastrointestinal discomfort
The incidence of diarrhea is 15-20%. It is recommended to have small meals and avoid high-fat diets. Persistent diarrhea requires electrolyte supplementation, and in severe cases, consider reducing or suspending medication.
3. Abnormal liver function
About 5% of patients experience elevated transaminase levels. Baseline testing is required before treatment, and follow-up examinations are conducted every 3 months during the treatment period. If the ULN exceeds 3 times, treatment should be interrupted and liver protection measures should be taken.
Serious Adverse Reaction Management
1. Allergic reactions
Rare but may cause vascular edema or rash. If there is difficulty breathing and facial swelling, the medication should be stopped immediately and antihistamine treatment should be given. If necessary, adrenaline should be used.
2. Abnormal blood system
Possible thrombocytopenia may occur. Regular blood routine monitoring to avoid trauma. If abnormal bleeding is detected, seek medical attention promptly and administer platelet transfusions if necessary.
Precautions for special populations
1. Elderly patients
More prone to falls and arrhythmia. Suggest halving the initial dose, strengthening electrocardiogram monitoring and fall prevention measures.
2. Liver and kidney dysfunction
Patients with moderate liver function impairment need to adjust the dosage by 50%. Patients with end-stage renal disease are prohibited from using it, and those with creatinine clearance rate<30ml/min should use it with caution.
Drug interaction prevention
1. CYP3A4 inducer
Avoid using strong inducers such as rifampicin in combination, as it may reduce blood drug concentration by more than 50%. When it is necessary to use it together, the dose of Acomidi should be increased.
2. Antiarrhythmic drugs
Combined use with amiodarone may exacerbate QT interval prolongation. When used in combination, closely monitor the electrocardiogram and adjust the dosage if necessary.
Disclaimer：《Side effects and mitigation methods of Acoramidis in Laos》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！