Side effects, relief methods, and medication precautions of CrineticsPalsonify (Paltusotine) in the United States
Palsonify (Paltusotine) is a medication used to treat acromegaly, and its side effects involve multiple systems, requiring targeted relief measures. The following will explain the management of common side effects, response to serious adverse reactions, and medication precautions to help patients safely use medication.
1. Common side effects and alleviation
(1) Gastrointestinal reactions
About 30% of patients experience nausea and diarrhea. It is recommended to take medication after meals and drink small amounts of water in portions. Short term use of antiemetic drugs may be considered for persistent symptoms.
(2) Headache and dizziness
The incidence rate is about 18% -22%, and it is obvious in the initial treatment stage. Maintain sufficient water intake, avoid sudden changes in position, and use acetaminophen if necessary to alleviate symptoms.
2. Response to serious adverse reactions
(1) Abnormal liver function
If jaundice or darkened urine color occurs, the medication should be stopped immediately. ALT/AST should be monitored before treatment and every 3 months. If it increases by more than 3 times, medication should be suspended.
(2) Disruption of blood glucose metabolism
Regular monitoring of fasting blood glucose, diabetes patients need to adjust the hypoglycemic program. Seek medical attention promptly when experiencing symptoms of excessive drinking and urination.
3. Medication precautions
(1) Liver function monitoring
ALT/AST should be tested before treatment, and rechecked every 3 months during the treatment period. If jaundice or transaminase elevation is more than three times, the medication should be stopped immediately for evaluation.
(2) Blood sugar management
It may cause blood sugar fluctuation, and diabetes patients need to strengthen monitoring. When symptoms such as polyuria and thirst occur, the hypoglycemic plan should be adjusted in a timely manner.
(3) Cardiovascular assessment
Before medication, it is necessary to screen for the risk of QT interval prolongation and avoid co administration with arrhythmogenic drugs. Regularly monitor electrocardiogram and electrolytes.
(4) Prevention of bleeding risk
Avoid combining with anticoagulants, and immediately check platelet function in case of abnormal bleeding. The necessity of discontinuing medication should be evaluated before surgery.
(5) Light sensitive protection
Strict sun protection measures should be taken during medication. It is recommended to use broad-spectrum sunscreen and avoid direct sunlight at noon.
Disclaimer：《Side effects, relief methods, and medication precautions of CrineticsPalsonify (Paltusotine) in the United States》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！