Taboo populations, foods, and restrictions of CrineticsPalsonify (Paltusotine) in the United States
Palsonify (Paltusotine) is mainly used to treat specific endocrine disorders, and its medication must strictly follow clinical guidelines to ensure efficacy and safety. This article will provide a detailed introduction from the following aspects.
1. Scope of indications
(1) Acromegaly
Suitable for adult patients with acromegaly who have poor response to surgery or radiotherapy, it can significantly reduce the levels of growth hormone and insulin-like growth factor-1.
2. Taboo population
(1) Pregnant women
Explicitly prohibited, animal experiments have shown that it can cause fetal craniofacial deformities and embryonic death. Women of childbearing age need to confirm that they are not pregnant before taking medication, and continuous contraception is required from the treatment period until one month after discontinuing the medication.
(2) Severe liver dysfunction
Child Pugh C patients are absolutely contraindicated as it may worsen liver damage. Assess liver function before medication and regularly monitor transaminase levels during treatment.
(3) Allergic individuals
It is contraindicated for individuals allergic to somatostatin analogs, as there may be hypersensitivity reactions such as urticaria and angioedema, and emergency measures should be taken.
3. Forbidden foods
(1) Grapefruit products
It is prohibited to consume grapefruit juice or related fruits, as the furan coumarin it contains can inhibit CYP3A4 metabolic enzymes, leading to abnormally high blood drug concentrations.
(2) High-fat diet
Avoid taking with fried foods as it may delay drug absorption. It is recommended to take it one hour after meals to ensure medication stability.
4. Restrictive conditions
(1) Cardiovascular disease
Patients with QT interval prolongation should use caution and require baseline electrocardiogram examination. Avoid using diuretics in combination to prevent electrolyte imbalance from exacerbating arrhythmia.
(2) Renal insufficiency
Patients with eGFR<30mL/min need to reduce their dosage by 50% and monitor creatinine levels weekly. Hemodialysis patients should receive medication after dialysis.
(3) Combination medication
Do not use potent CYP3A4 inhibitors (such as clarithromycin) in combination, and adjust the dosage when used with SSRI antidepressants.
Disclaimer：《Taboo populations, foods, and restrictions of CrineticsPalsonify (Paltusotine) in the United States》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！