Taboo populations, foods, and restrictions for AstraZeneca's version of Tamoxifen
Tamoxifen is a selective estrogen receptor modulator, mainly used for the treatment and prevention of breast cancer. The following is an explanation from three aspects: taboo populations, taboo foods, and restrictive conditions, based on drug instructions and clinical medication guidelines.
1. Taboo population
(1) Pregnant women
Tamoxifen may cause fetal malformations and is contraindicated during pregnancy. Before medication, it is necessary to confirm the pregnancy status, and effective contraceptive measures should be taken during the treatment period and 2 months after discontinuation of medication.
(2) Lactating women
Medications can be secreted into breast milk and may cause serious adverse reactions to infants. They should be contraindicated during lactation.
(3) Deep vein thrombosis/pulmonary embolism patients
Tamoxifen may increase the risk of thrombosis and is contraindicated for such patients.
(4) Severe liver dysfunction patients
The drug is metabolized by the liver and is contraindicated for patients with severe liver dysfunction (Child Pugh C grade).
(5) People who are allergic to drug ingredients
It is contraindicated for individuals who have previously been allergic to tamoxifen or excipients.
2. Forbidden foods
(1) Grapefruit/Grapefruit Juice
Possible inhibition of CYP3A4 enzyme may increase the blood concentration and toxicity risk of tamoxifen, and co administration should be avoided.
(2) Alcohol
Long term heavy alcohol consumption may increase the burden on the liver and affect drug metabolism. It is recommended to limit intake.
(3) High-fat diet
May delay drug absorption, it is recommended to take it on an empty stomach at a fixed time or with a low-fat meal.
3. Restrictive conditions
(1) Risk of endometrial cancer
Long term use requires regular gynecological examinations to be alert to the risk of endometrial thickening or cancer.
(2) Liver function monitoring
Regular liver function tests should be conducted before and during treatment, and moderate damage should be reduced.
(3) Ophthalmic examination
May cause retinal lesions and require immediate medical attention if visual changes occur.
(4) Drug interactions
CYP2D6 strong inhibitors (such as fluoxetine) may reduce efficacy and should be avoided in combination or adjusted in dosage.
(5) Bone density monitoring
Long term use in postmenopausal women may accelerate bone loss, and it is recommended to supplement calcium supplements and vitamin D.
Disclaimer：《Taboo populations, foods, and restrictions for AstraZeneca's version of Tamoxifen》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！