Medical Information

Regorafenib is an oral multi-target inhibitor, and its efficacy relies on precise dosage execution and rigorous adverse event monitoring. The following focuses on the core points in clinical practice, without involving mechanisms or statistical data.

1、 Standard usage and dosage

dosage regimen

The recommended starting dose is 160mg (4 tablets), once a day, taken whole tablets in warm water after a low-fat meal (fat content<30%).

Cycle Settings

Adopting an intermittent regimen of "taking medication for 3 weeks+stopping medication for 1 week" (i.e. every 4 weeks as a cycle). Do not arbitrarily shorten the withdrawal period or split the pills.

Dose adjustment ladder

If serious adverse reactions occur, reduce the dosage in sequence to 120mg → 80mg. Once the dosage is reduced to 80mg but still intolerable, permanent discontinuation of the medication is required.

2、 Basis for efficacy evaluation

Imaging time window

The first efficacy evaluation is usually conducted after 2 cycles (8 weeks) of treatment, and early evaluation may lead to misjudgment of "pseudo progression".

Symptom relief signal

Stable physical condition, reduced tumor related pain, or weight gain can serve as indirect efficacy references, but cannot replace imaging examinations.

3、 Key precautions

Hepatotoxicity monitoring

Liver function should be checked before treatment and on the first day of each cycle. If ALT/AST>5 times the normal upper limit or bilirubin>3 times the upper limit, immediately suspend administration.

Blood pressure and hand and foot skin management

Measure blood pressure at a fixed time every day (target<140/90mmHg); When there is redness, swelling or peeling on the hands and feet, avoid soaking in hot water and use urea ointment to moisturize and reduce friction.

Principles for handling diarrhea

When loose stool occurs, first take oral rehydration salts to maintain water electrolyte balance; If more than 4 times within 24 hours, it is necessary to contact a doctor for evaluation. Do not use strong antidiarrheal drugs on your own to cover up the risk of dehydration.

Drug interaction warning

Avoid co administration with potent CYP3A4 inducers (such as rifampicin) or inhibitors (such as ketoconazole); If necessary, adjust the dosage under the guidance of a pharmacist.