Guidelines for taking osimertinib: on an empty stomach or with meals? Dose adjustment and treatment of missed doses
The correct way of taking Axitinib directly affects its efficacy and safety. Mastering the timing of medication, principles of dosage adjustment, and methods for handling missed doses are key to ensuring standardized treatment.
1、 Medication method and timing
1. Fasting or with meals?
Axitinib is not affected by food and can be taken on an empty stomach or with meals. But it is recommended to take medication at a fixed time every day to maintain a stable blood drug concentration.
2. How to take it?
Swallow the whole piece and take it with plenty of water. Do not chew, crush, or pry open the pill.
2、 Principle of dose adjustment
3. Standard dose
The recommended dosage is once daily, 80mg each time, unless otherwise instructed by a doctor.
4. Reduction of adverse reactions
When serious adverse reactions occur (such as interstitial lung disease, severe diarrhea, or rash), doctors may suspend medication or reduce dosage to 40mg once daily. After resuming medication, do not add back the original dose without authorization, and gradually adjust according to medical advice.
5. Adjustment of combined medication
When used in combination with potent CYP3A4 inducers such as rifampicin and phenytoin sodium, the blood concentration of osimertinib may decrease and may require an increase in dosage, but it must be done under the guidance of a doctor and cannot be adjusted on its own.
3、 Handling of missed services
6. Supplementary service rules
If missed once, take it immediately. But if it is less than 12 hours before the next scheduled medication time, the missed dose will be skipped and the next dose will be taken according to the original plan.
7. Prohibition of double dosage
Do not take double the dose during the next medication due to missed doses to avoid toxicity accumulation.
4、 Precautions during medication
8. Fixed daily time
It is recommended to take medication at the same time every morning to develop a regular habit and reduce the possibility of missed doses.
9. Treatment after vomiting
If vomiting occurs after taking the medication, the daily dose should not be taken, and the next day's dose should be taken according to the usual time.
Disclaimer：《Guidelines for taking osimertinib: on an empty stomach or with meals? Dose adjustment and treatment of missed doses》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！