People contraindicated for osimertinib: severe liver and kidney dysfunction, pregnant women and patients should be aware of it
Axitinib is a targeted drug for lung cancer, but it needs to be discontinued or used with caution in some populations due to safety risks. The following are key taboos and precautions.
1、 Absolutely prohibited population
1. Individuals allergic to osimertinib or its excipients
Individuals with a history of allergic reactions are strictly prohibited from using it.
2. Those who are using St. John's wort (Forsythia suspensa)
This herb significantly reduces the blood concentration of Axitinib, leading to treatment failure, and its combination is prohibited.
2、 Severe liver and kidney dysfunction patients
3. Severe liver dysfunction (Child Pugh C grade)
Patients with severe liver injury have significantly increased drug exposure and increased risk of toxicity, and are generally not recommended for use; If medication is necessary, it should be reduced under close monitoring.
4. End stage renal disease (creatinine clearance rate<30mL/min) or dialysis patients
This group of people lacks sufficient safety data and it is not recommended to use osimertinib.
3、 Pregnant and lactating women
5. Pregnant women
Animal studies have shown that osimertinib can cause fetal damage and is contraindicated during pregnancy. Women with fertility must take effective contraceptive measures during treatment and within 6 weeks after discontinuing medication.
6. Breastfeeding women
Medications may be excreted through breast milk and have potential serious adverse effects on infants. Breastfeeding is prohibited during the treatment period and within 2 weeks after discontinuation of medication.
4、 Other populations that require caution
7. Patients with a history of interstitial lung disease/pneumonia
Individuals with a history of interstitial lung disease, drug-induced pneumonia, or radiation pneumonitis who are at increased risk of severe pulmonary toxicity during medication should use with caution and closely monitor respiratory symptoms.
8. Men with fertility
Male patients should use condoms during treatment and within 4 months after discontinuing medication to avoid impregnating their partners, as medication may affect sperm quality and fetal development.
Disclaimer：《People contraindicated for osimertinib: severe liver and kidney dysfunction, pregnant women and patients should be aware of it》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！