Management of side effects of Axitinib: How to deal with diarrhea, rash, and stomatitis
Osimertinib is an oral third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).
1. Diarrhea management
Mild (daily increase ≤ 3 times): Take oral rehydration salts, avoid high fiber, greasy and dairy products; You can try montmorillonite powder or loperamide.
Moderate to severe (daily increase ≥ 4 times or symptoms of dehydration): Suspend Axitinib and contact a doctor; Electrolyte supplementation is required, and hospitalization for fluid replacement may be necessary.
Warning: If there is bloody stool, severe abdominal pain, or fever, seek medical attention immediately to rule out intestinal obstruction or infection.
2. Skin rash management
Daily care: Use a mild soap free cleanser and apply a fragrance free moisturizer daily; Avoid direct sunlight and use broad-spectrum sunscreen with SPF ≥ 30.
Classification processing:
Mild (local papules/erythema): Apply topical weak acting hormones (such as hydrocortisone) or antibiotic ointments (such as clindamycin).
Moderate to severe (extensive rash with itching/pain): Take doxycycline or minocycline orally according to the doctor's advice, and add medium to strong topical hormones.
Taboo: Do not squeeze or use irritating skincare products on your own; If the rash is accompanied by fever or blisters, discontinue medication and seek emergency treatment.
3. Management of Stomatitis
Basic care: Use soft bristled toothbrushes and fluoride toothpaste; Rinse your mouth with physiological saline or sodium bicarbonate solution after meals, avoiding mouthwash containing alcohol.
Pain intervention: Lidocaine gargle or benzocaine gel can be used for local pain relief before eating.
Dietary adjustment: Choose warm and cool soft foods, and avoid acidic, spicy, or rough foods.
Medical indications: If white patches (indicating fungal infection), ulcer surface enlargement, or inability to eat occur, Osimertinib should be discontinued and antifungal (such as antifungal) or systemic analgesic treatment should be initiated.
Disclaimer：《Management of side effects of Axitinib: How to deal with diarrhea, rash, and stomatitis》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！