Managing the side effects of Rabelase: How to deal with fever, vomiting, and rash
The possible side effects such as fever, vomiting, and rash during treatment with Fasturtec require targeted management. The following systematically explains the coping strategies from three aspects: symptom recognition, grading treatment, and preventive measures, to ensure a balance between medication safety and efficacy.
1. Heat management
(1) Identification and monitoring: Fever often occurs within 24 hours after administration, and if the body temperature is ≥ 38 ℃, one should be alert to allergic reactions or infections. It is recommended to monitor body temperature every 4 hours, record fever patterns and accompanying symptoms.
(2) Grading treatment: Low heat (<38.5 ℃) can be physically cooled down; For moderate to high fever (≥ 38.5 ℃), medication should be suspended and infection should be investigated. If accompanied by chills or allergic signs, immediately administer dexamethasone 5-10mg intravenously.
2 Vomit control
(1) Preventive medication: Combining 5-HT3 receptor antagonists (such as ondansetron) 30 minutes before chemotherapy can reduce the incidence rate. Severe vomiting patients should receive intravenous injection of 10mg dexamethasone.
(2) Emergency response: In case of explosive vomiting, oral administration of aripipitan or intramuscular injection of metoclopramide should be administered. If vomiting persists for more than 24 hours, assess the risk of electrolyte imbalance and correct it with fluid replacement if necessary.
3 Skin rash intervention
(1) Allergy identification: Spotted papules with itching are mostly mild allergies, and it is necessary to stop using Rabelase and take oral loratadine 10mg/day. The occurrence of urticaria or angioedema is a serious reaction and requires adrenaline intervention.
(2) Skin care: For local rashes, apply hydrocortisone cream to avoid scratching. When the mucosa is affected (such as oral ulcers), rinse your mouth with physiological saline 4-6 times a day.
4 Comprehensive preventive measures
(1) Pre medication screening: Detailed inquiry of allergy history, only those who test negative for G6PD can use it. Observe for at least 2 hours after the first administration and equip with emergency equipment.
(2) Patient education: Guide the identification of early side effect symptoms, such as skin erythema, nausea precursors, etc. Any abnormalities should be reported immediately to medical staff to avoid delaying the processing time.
Disclaimer：《Managing the side effects of Rabelase: How to deal with fever, vomiting, and rash》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！