Storage method and medication precautions for Bedaquiline in Laos bear
The storage of Bedaquiline requires strict control of temperature and humidity conditions, and special attention should be paid to cardiac toxicity and drug interaction risks when using it. The following is a detailed explanation of specific storage standards and medication precautions.
1. Storage conditions
Unopened bedaquiline should be stored in its original packaging and protected from light in a refrigerated environment at 2-8 ° C. Freezing or exposure to high temperatures is prohibited. If it is a tablet after opening, it should be used up within 30 days and the desiccant inside the bottle should be kept intact.
2. Medication precautions
(1) Cardiac monitoring
Regular monitoring of electrocardiogram and attention to changes in QT interval is required before treatment and during medication. If QTc exceeds 500ms, the medication should be stopped immediately and electrocardiogram monitoring should be continued until it returns to normal.
(2) Liver function monitoring
ALT/AST levels should be checked monthly. If jaundice or transaminase elevation reaches three times the normal value, treatment should be interrupted and liver protection support therapy should be given.
(3) Drug interactions
The combination of potent CYP3A4 inhibitors (such as ketoconazole) or inducers (such as rifampicin) is prohibited, as it may cause severe fluctuations in blood drug concentration or treatment failure.
(4) Medication for special populations
Patients with severe liver injury are prohibited from using it, and the dosage needs to be adjusted for mild to moderate cases. Pregnant women can only use drug resistant tuberculosis when there is no alternative plan, and the risk benefit ratio needs to be strictly evaluated.
(5) Handling of missed services
If the missed dose is not taken for more than 12 hours, it can be supplemented. If it exceeds 12 hours, the dose will be skipped and double dose remediation is prohibited.
(6) Adverse reaction response
Seek medical attention immediately when experiencing cardiac symptoms such as chest pain, fainting, or persistent nausea and vomiting. At present, there is no specific antidote, and symptomatic supportive treatment is the main approach.
Disclaimer：《Storage method and medication precautions for Bedaquiline in Laos bear》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！