Medical Information

Special attention should be paid to drug interactions, special population risks, and long-term medication management when using Chlorphenesin Carbamate tablets in Japan. The following provides a detailed explanation of the special precautions for this medication from six aspects to help patients use it safely.

1. Risks of drug interactions

(1) Central nervous system inhibitors: When used in combination with alcohol and sedatives, they can enhance central nervous system inhibitory effects and require dosage adjustment;

(2) Liver enzyme inducers: Barbital drugs may reduce their efficacy, and treatment efficacy needs to be monitored;

(3) Muscle relaxants: Combination with other skeletal muscle relaxants may worsen muscle weakness symptoms.

2. Medication for special populations

(1) Liver dysfunction: Reduce usage by 50% and monitor ALT/AST indicators every 2 weeks;

(2) Renal insufficiency: When creatinine clearance rate is less than 30ml/min, the dosing interval is extended to 12 hours;

(3) Elderly people: The starting dose should be 1/2 of the regular dose, and caution should be taken against orthostatic hypotension.

3. Long term medication management

(1) Course limit: Continuous use for no more than 3 weeks to avoid drug dependence;

(2) Discontinuation method: Gradually reduce dosage within 1-2 weeks to prevent rebound spasms;

(3) Efficacy evaluation: If the medication is ineffective for 2 weeks, a new diagnosis is required and the use beyond the indications is prohibited.

4. Precautions for operating machinery

(1) Driving safety: Do not drive or work at heights within 8 hours after taking medication;

(2) Precision operation: may affect hand coordination, and should be stopped for 24 hours before proceeding;

(3) Risk period: Special attention should be paid to drowsiness reactions after the first medication or dose adjustment.

5. Handling of Allergic Reactions

(1) Identification features: Immediate rescue is required in case of laryngeal edema and bronchospasm;

(2) Cross allergy: Prohibited for individuals allergic to procaine, as cross reactions may occur;

(3) Emergency preparedness: Individuals with a history of allergies should prepare an adrenaline automatic injector.

6. Other important warnings

(1) Risk of aspiration: Patients with swallowing difficulties need to crush and take with food;

(2) Drug abuse: with mild addictive nature, medication should be strictly dispensed according to the prescribed dosage;

(3) Temperature effect: Storing above 30 ℃ may reduce the efficacy of the medicine and requires refrigeration storage.