Medical Information

During the use of talazoparib, attention should be paid to specific food and beverage intake restrictions, mainly involving substances that affect drug metabolism or worsen adverse reactions.

1. Grapefruits and their products

(1) Absolute avoidance: Grapefruits, grapefruit juice, and other products containing furanocoumarin can significantly inhibit CYP3A4 enzyme activity;

(2) Risk mechanism: It may lead to an abnormal increase in the blood concentration of tacrolimus, increasing the risk of toxicity such as bone marrow suppression;

(3) Alternative options: Fruits that do not affect metabolism, such as oranges and apples, can be chosen.

2. Alcoholic beverages

(1) Restriction of intake: Alcohol may increase the metabolic burden on the liver, especially in patients with liver dysfunction;

(2) Synergistic effect: Combined with the risk of drug-induced liver injury, it is recommended to abstain from alcohol during treatment;

(3) Special occasions: If alcohol consumption is necessary, it should be kept to a minimum and liver function should be closely monitored.

3. High fat diet

(1) Avoid taking during meals: High fat foods can delay drug absorption, and it is recommended to take them on an empty stomach or one hour after a low-fat meal;

(2) Long term effects: Obese patients need to pay attention to controlling fat intake to prevent affecting drug distribution and metabolism;

(3) Dietary advice: Prioritize choosing light and easily digestible proteins and vegetables.

4. Foods containing caffeine

(1) Moderate control: Coffee, strong tea, etc. may affect drug metabolism through CYP1A2 interactions;

(2) Symptom management: Daily caffeine intake should not exceed 200mg (approximately 2 cups of coffee);

(3) Alternative drinks: You can choose herbal tea or low caffeine drinks.

5. Fresh and cold seafood

(1) Caution in consumption: may increase the risk of gastrointestinal discomfort, especially in patients with thrombocytopenia;

(2) Safe handling: Ensure complete cooking to avoid parasitic or bacterial infections;

(3) Nutritional replacement: Protein can be supplemented through cooked poultry or soy products.