Side effects and mitigation methods of Cipla Deferasirox in India
Deferasirox is an iron chelator primarily used to treat chronic iron overload. Its side effects involve multiple systems and can be effectively alleviated through rational medication and monitoring. The following is a detailed explanation of the side effects and countermeasures of the drug.
1. Common side effects and alleviation
(1) Gastrointestinal reactions
Nausea, vomiting, and abdominal pain are common, and it is recommended to take them with meals or in divided doses. If symptoms persist, consider reducing dosage or combining proton pump inhibitors.
(2) Skin reaction
The incidence of rash is about 10%, and mild rash can disappear on its own. Severe rash requires discontinuation of medication and treatment with antihistamines.
(3) Headache and dizziness
It often occurs in the early stages of treatment, and maintaining sufficient water intake can alleviate it. Avoid sudden changes in posture.
2. Serious side effects to be wary of
(1) Hepatorenal toxicity
Regular monitoring of liver and kidney function is crucial. If ALT rises more than 5 times the normal value or creatinine continues to rise, the medication should be stopped immediately.
(2) Abnormal blood system
May cause granulocyte reduction, blood routine should be checked monthly during treatment. Fever and infection symptoms require timely medical attention.
(3) Allergic reactions
Manifesting as facial swelling or difficulty breathing, with an incidence rate of less than 1%, but requiring immediate discontinuation of medication and emergency treatment.
3. Precautions for special populations
(1) Elderly patients
Patients with renal dysfunction need to adjust their dosage, and it is recommended to start at 50% of the regular dose.
(2) Child patients
Children over 2 years old can use it, but the dosage must be strictly calculated based on body weight and monitored for growth and development.
(3) Pregnancy and lactation period
Pregnant women are prohibited from using medication, and breastfeeding should be suspended during lactation.
4. Drug interaction management
(1) Antacid drugs
Aluminum containing antacids can reduce the absorption of Deferasirox and should be taken at least 2 hours apart.
(2) CYP450 inducer
Levofloxacin and other drugs may reduce the concentration of Deferasirox, and when used in combination, the dosage needs to be increased by 30%.
(3) Anticoagulant drugs
May enhance the effectiveness of warfarin, and INR values need to be closely monitored during combination use.
Disclaimer：《Side effects and mitigation methods of Cipla Deferasirox in India》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！