The efficacy and drug interactions of Syprine
Syprine, as a copper chelator, is mainly used for the treatment of Wilson's disease, promoting its excretion by specifically binding to copper ions. The effect and drug interaction of its action need to be focused on, and the following will explain it from two aspects: pharmacological mechanism and drug interaction.
1. Effect of action
(1) Copper ion chelation: Quentin can form stable complexes with free copper ions in the body, promote copper excretion through urine, and reduce tissue copper deposition.
(2) Organizational protection: Relieve symptoms related to Wilson's disease by reducing the accumulation of copper in organs such as the liver and central nervous system.
(3) Long term efficacy: Continuous medication is required to maintain copper metabolism balance, and regular monitoring of urinary copper and serum ceruloplasmin levels is necessary to evaluate efficacy.
2. Drug interactions
(1) Iron/zinc agents: may competitively bind to quercetin, reducing copper chelation effect. It is recommended to take them at intervals of more than 2 hours.
(2) Antacids: Antacids containing aluminum, calcium, and magnesium may affect absorption and should be administered at staggered times (at least 1 hour).
(3) Penicillamine: Avoid combination therapy as it may increase the risk of bone marrow suppression. A 2-week washout period is required when switching treatment.
(4) CYP450 substrate: Currently, no significant enzyme induction or inhibition has been found, but changes in therapeutic efficacy still need to be monitored when combined with medication.
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