What is the therapeutic effect of TRPharm version of Syprine? Is there anything to pay attention to when patients stop taking medication?
Syprine is a copper chelator primarily used to treat Wilson's disease (Wilson's disease) by promoting copper excretion to improve symptoms. Its therapeutic effect is significant but requires long-term medication. Discontinuation of medication should be carefully evaluated and gradually reduced, while closely monitoring copper metabolism indicators.
1. Therapeutic effect
(1) Efficacy performance
Quentin can effectively reduce serum free copper levels, improve neurological symptoms and liver dysfunction. Most patients show symptom relief after 3-6 months of treatment, but continuous medication is needed to maintain efficacy.
(2) Therapeutic efficacy monitoring
During the treatment period, regular monitoring of 24-hour urinary copper excretion, serum free copper, and liver function is required. The ideal therapeutic effect is to maintain urinary copper at 250-500 μ g/24h and serum free copper<10 μ g/dL.
2. Precautions for discontinuation of medication
(1) Indications for discontinuation of medication
Only when copper metabolism indicators remain normal for at least 1 year and there are no clinical symptoms, should a specialist evaluate and decide whether to reduce or discontinue. Sudden discontinuation of medication may lead to a rebound in copper accumulation.
(2) Discontinuation method
Gradual reduction should be adopted, reducing the dose by 250mg every 2-3 months until complete discontinuation. During the reduction period, it is necessary to strengthen monitoring of urinary copper and serum ceruloplasmin.
(3) Monitoring after discontinuation of medication
Recheck copper metabolism indicators every 3 months in the first year after discontinuation, and every 6 months thereafter. If there are abnormal indicators or symptoms recur, treatment should be restarted immediately.
(4) Special populations
Pregnant patients should not stop taking medication, but may reduce it at their discretion. Childhood patients have a higher risk of recurrence after discontinuing medication and need to extend the monitoring period to adulthood.
Disclaimer：《What is the therapeutic effect of TRPharm version of Syprine? Is there anything to pay attention to when patients stop taking medication?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！