How effective is the treatment of Vibegron in Laos? Is there anything to pay attention to when patients stop taking medication?
Vibegron is a beta 3 adrenergic receptor agonist primarily used for the treatment of overactive bladder (OAS). It promotes urinary storage function by activating bladder smooth muscle β 3 receptors, and has been clinically shown to significantly improve symptoms of urinary frequency, urgency, and urgency. The following provides a detailed explanation from two aspects: treatment effectiveness and precautions for discontinuing medication.
1. Therapeutic effect
(1) Symptom improvement
Clinical studies have shown that after 12 weeks of treatment with Vibergron, the daily frequency of urination can be reduced by 1.5-2 times, and the occurrence of urgent urinary incontinence can be reduced by 2-3 times per day, with better effects than the placebo group.
(2) Effective time
Most patients experience symptom improvement within 1-2 weeks of medication, and the maximum treatment effect is achieved within 4-8 weeks. It is recommended to continue medication for at least 12 weeks to evaluate its efficacy.
(3) Long term therapeutic effect
The 52 week extension study confirmed that the therapeutic effect can be sustained and there was no significant decrease in tolerability. The therapeutic effect of elderly patients (≥ 65 years old) is comparable to that of young patients.
2. Precautions for discontinuation of medication
(1) Indications for discontinuation of medication
The drug should be stopped immediately in case of urinary retention; Symptoms of angioedema (such as facial/throat swelling) require permanent discontinuation. Patients with poor therapeutic effects may consider discontinuing the medication after 12 weeks.
(2) Discontinuation method
Suggest stopping the medication directly without gradually reducing the dosage. But when using potent CYP3A4 inhibitors in combination, the inhibitor needs to be stopped for 5 days before stopping Vebeclone.
(3) Monitoring after discontinuation of medication
Monitor blood pressure changes within one week after discontinuing medication (especially for hypertensive patients); Those who use digitalis drugs in combination need to continuously monitor their blood drug concentration.
(4) Discontinue medication for special populations
Patients with liver dysfunction need to extend monitoring to 2 weeks after discontinuing medication; Breastfeeding women are advised to pause breastfeeding for another week after discontinuing medication.
Disclaimer：《How effective is the treatment of Vibegron in Laos? Is there anything to pay attention to when patients stop taking medication?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！