Indications and medication precautions for the Glenmark version of Aprilast in India
Aprilast is a phosphodiesterase 4 (PDE4) inhibitor mainly used to treat psoriatic arthritis and plaque psoriasis. When using it, attention should be paid to adverse reactions such as diarrhea and depression, as well as medication adjustments for special populations.
1. Indications
(1) Psoriatic arthritis
Suitable for adult patients with active psoriatic arthritis, it can improve physical symptoms and inhibit the progression of structural damage.
(2) Plaque psoriasis
Suitable for adult patients with moderate to severe plaque psoriasis and candidates for phototherapy or systemic therapy.
2. Medication precautions
(1) General precautions
The dosage needs to be gradually titrated to reduce gastrointestinal adverse reactions, starting at 10mg once daily and reaching a maintenance dose of 30mg twice daily on the 6th day.
(2) Adverse reaction management
Common gastrointestinal reactions such as diarrhea and nausea usually occur in the early stages of treatment. If persistent diarrhea occurs, assess the risk of dehydration and consider reducing the dosage.
(3) Mental health monitoring
May exacerbate depression or trigger suicidal ideation, it is necessary to evaluate the history of mental illness before medication and closely monitor emotional changes during treatment.
(4) Medication for special populations
Due to limited data during pregnancy, women of childbearing age need contraception; Not recommended for use during lactation; Severe renal insufficiency requires a reduction to 30mg once daily.
Disclaimer：《Indications and medication precautions for the Glenmark version of Aprilast in India》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！