Indications and medication precautions for Mekinist, the Laotian version of the bear drug
Mekinist, as a MEK1/2 inhibitor, is mainly used for the treatment of BRAFV600 mutation positive tumors. Its indications include melanoma and non-small cell lung cancer, and special attention should be paid to cardiovascular, ocular, and skin toxicity risks during medication. The following provides a detailed explanation from two aspects: indications and medication precautions.
1. Indications
(1) Melanoma
Monotherapy or combination therapy with dalafenib can significantly prolong progression free survival in BRAFV600E/K mutation positive unresectable or metastatic melanoma.
(2) Non small cell lung cancer
The combination of dalafenib for first-line treatment of BRAFV600E mutation positive metastatic non-small cell lung cancer achieved an objective response rate of 64%.
2. Medication precautions
(1) Cardiovascular toxicity
May cause left ventricular dysfunction, regular monitoring of cardiac function is necessary before and during treatment, and symptomatic heart failure should be reduced or discontinued.
(2) Eye effects
It can cause retinal vein occlusion, serous retinopathy, etc. Patients with visual impairment should immediately undergo ophthalmic evaluation and adjust the dosage.
(3) Skin reaction
Common rashes, photosensitivity reactions, and in severe cases, Stevens Johnson syndrome may occur, requiring sun protection and monitoring of skin symptoms.
(4) Risk of bleeding
Combination therapy may increase the risk of gastrointestinal or intracranial bleeding, and permanent discontinuation of medication may be necessary in the event of severe bleeding.
(5) Embryotoxicity
Women of childbearing age should confirm their pregnancy status before taking medication, and take effective contraceptive measures during treatment and 4 weeks after discontinuing medication.
(6) Liver function monitoring
During the treatment period, ALT/AST should be tested monthly. If liver toxicity occurs, medication should be interrupted until recovery, and subsequent reduction or discontinuation of medication should be carried out.
Disclaimer：《Indications and medication precautions for Mekinist, the Laotian version of the bear drug》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！