Medical Information

Deucravatinib is an oral TYK2 inhibitor used to treat autoimmune diseases such as moderate to severe plaque psoriasis. Its common side effects include increased risk of infection, headache, diarrhea, etc., most of which are mild to moderate and controllable, and need to be managed through regular monitoring, symptomatic treatment, and lifestyle adjustments.

1. Common side effects and coping strategies

(1) Infection risk: It may increase the risk of upper respiratory tract infection. It is recommended to avoid contact with infectious sources and seek medical attention if fever or persistent cough occurs.

(2) Digestive system reactions: such as diarrhea, adjust diet structure and supplement electrolytes; Nausea and vomiting can be taken in divided doses or with meals.

(3) Headache: usually brief, maintain sufficient rest, and use analgesics such as acetaminophen if necessary to relieve it.

2. Serious side effects to be wary of

(1) Opportunistic infection: tuberculosis recurrence or fungal infection may occur, and tuberculosis screening should be conducted before medication, and infection signs should be monitored during treatment.

(2) Allergic reactions: If there is a rash, facial swelling, or difficulty breathing, the medication should be stopped immediately and emergency treatment should be sought.

(3) Abnormal laboratory indicators: Regularly check liver and kidney function, blood routine, and intervene promptly if elevated transaminase or decreased blood cells are found.

3. Precautions for special populations

(1) Pregnant women are prohibited from using: there is a potential risk of teratogenicity, and women of childbearing age should take effective contraceptive measures until 4 weeks after discontinuing the medication.

(2) Liver dysfunction: Patients with moderate to severe liver damage need to adjust the dosage and monitor liver function every 3 months during baseline and treatment.

(3) Elderly patients: more prone to infection, it is recommended to strengthen vaccination (such as influenza vaccine, pneumococcal vaccine).

4. Comprehensive management strategy

(1) Medication education: Inform patients of the complete medication plan to avoid missing or self stopping medication.

(2) Lifestyle: Keep the skin clean and moisturized, avoid excessive sun exposure, and have a balanced diet to enhance immunity.

(3) Follow up plan: Establish a regular follow-up mechanism, including comprehensive physical examinations and laboratory evaluations every 3 months.