Medical Information

The contraindications for ribociclib mainly include severe allergic reactions, specific heart diseases, and severe liver injury. For special populations, the dosage should be adjusted or monitored according to liver and kidney function, pregnancy status, and age.

1. Contraindications

(1) It is contraindicated for individuals who are allergic to Raboxetine or its excipients, as it may cause serious hypersensitivity reactions such as rash or difficulty breathing.

(2) Patients with QT prolongation syndrome or uncontrolled arrhythmia are contraindicated as the medication may exacerbate cardiac conduction abnormalities.

(3) Patients with Child Pugh C grade liver dysfunction are contraindicated, as significant restriction in drug metabolism may lead to cumulative toxicity.

2. Medication for special populations

(1) Pregnancy and lactation period

Pregnant women are prohibited from using it, as animal studies have shown embryotoxicity (such as abnormal bone development); Breastfeeding should be suspended during lactation, as medication may be secreted into breast milk.

(2) Liver dysfunction

Child Pugh A/B patients should reduce their dosage to 400mg once daily and regularly monitor their transaminase and bilirubin levels.

(3) Renal insufficiency

Mild to moderate damage (CLcr ≥ 30mL/min) does not require dose adjustment; Due to severe damage or insufficient data from dialysis patients, it is recommended to use with caution.

(4) Elderly patients

Patients aged 65 and above are more prone to neutropenia and require enhanced blood routine monitoring, but do not require routine reduction.

(5) Pediatric patients

The safety and efficacy of using it for patients under 18 years old have not been established, and it is not recommended.