What is Abrotinib? Can it be eaten for a long time? What are the contraindications and prohibited foods
Abrotinib is an oral JAK1 inhibitor primarily used for the treatment of moderate to severe atopic dermatitis. Long term use requires an evaluation of the risk benefit ratio, with contraindications including severe infections, liver dysfunction, etc. Specific food interactions should be avoided during medication.
1. Drug Overview
Abuxitinib is a highly selective JAK1 inhibitor that improves symptoms of atopic dermatitis by blocking inflammatory signaling pathways such as IL-4 and IL-13. Approved by the FDA in 2022 for patients aged 12 and above, it has been clinically shown to significantly alleviate itching and skin lesion area.
2. Long term usage evaluation
(1) Effectiveness: The longest observation period in clinical trials is 48 weeks, and maintenance treatment can delay recurrence.
(2) Safety: Long term use may increase the risk of infection and blood lipid abnormalities, and regular monitoring of blood routine, liver function, and blood lipid levels is necessary.
(3) Suggestion: Adjust the course of treatment based on symptom control, and continue medication for moderate to severe patients, but evaluate the necessity of treatment every 3-6 months.
3. Contraindications
(1) Patients with active tuberculosis or severe infections (such as sepsis) are contraindicated.
(2) Severe liver dysfunction (Child Pugh C grade) is contraindicated.
(3) Prohibited during pregnancy and lactation (animal studies have shown embryotoxicity).
(4) Prohibited for individuals with a history of allergy to JAK inhibitors.
(5) Patients with malignant tumors (especially lymphoma) need to be carefully evaluated.
4. Taboo foods and interactions
(1) Grapefruit/grapefruit juice: may inhibit CYP3A4 metabolic enzymes and increase the risk of blood drug concentration.
(2) High fat diet: It is recommended to take it on an empty stomach or 2 hours after meals, as fat may reduce absorption by 20%.
(3) Alcohol: may increase the metabolic burden on the liver, it is recommended to limit intake.
(4) St. John's wort: induces CYP3A4 enzyme, which may reduce drug efficacy.
Disclaimer：《What is Abrotinib? Can it be eaten for a long time? What are the contraindications and prohibited foods》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！