Precautions and drug interactions for the use of Ritlecitinib in Laos
The medication precautions for Ritlecitinib should pay attention to the monitoring of risks and adverse reactions in special populations. Drug interactions mainly involve the CYP enzyme system. The following provides a detailed breakdown of key content from two aspects: precautions and interactions.
1. Medication precautions
(1) Infection risk: It may increase the probability of bacterial, viral, or fungal infections. Before medication, it is necessary to screen for latent infections such as tuberculosis and monitor signs of infection during treatment.
(2) Cardiovascular events: Regularly assess blood pressure and lipid levels, especially for patients with a history of cardiovascular disease who need to strengthen monitoring.
(3) Malignant tumors: Long term use may increase the risk of malignant tumors such as lymphoma. Before medication, it is necessary to weigh the benefits and potential carcinogenicity.
(4) Liver function monitoring: ALT/AST should be regularly tested before and during treatment. If liver enzymes increase by more than 3 times ULN, medication should be discontinued.
(5) Vaccination: Avoid using live vaccines as inactivated vaccines may weaken their effectiveness during treatment.
2. Drug interactions
(1) Strong CYP3A4 inhibitor: may increase the blood concentration of rituximab, dosage adjustment or avoidance of combination therapy should be considered.
(2) Strong CYP3A4 inducer: may reduce the efficacy of rituximab, requiring monitoring of efficacy or increasing dosage.
(3) Hormonal contraceptive pills: may reduce contraceptive effectiveness, it is recommended to use non hormonal contraceptive measures.
(4) P-gp substrate drugs: May increase substrate drug exposure, caution should be exercised and adverse reactions monitored when combined.
(5) Immunosuppressants: may enhance immunosuppressive effects, increase the risk of infection, and avoid combination use.
Disclaimer：《Precautions and drug interactions for the use of Ritlecitinib in Laos》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！