Usage, Dosage, and Medication Guidelines for Selpercatinib
Selpercatinib is a RET kinase inhibitor used to treat RET fusion positive non-small cell lung cancer, thyroid cancer, and other malignant tumors. Its standard dose is 160mg orally twice daily, and it needs to be continued until disease progression or intolerable toxicity occurs.
1. Standard usage and dosage
(1) Adult patients: The recommended dosage is 160mg per dose, taken orally twice a day with an interval of about 12 hours, and should be swallowed whole.
(2) Pediatric patients: The dosage for patients aged 12 and above is the same as that for adults, but the safety and efficacy for patients under 12 years old have not been established.
(3) Duration of medication: Continuous treatment is required until disease progression or unacceptable toxic reactions occur.
2. Dose Adjustment Guidelines
(1) Grade 1 reduction: When grade 3 or above toxicity occurs, reduce to 120mg twice daily for the first time.
(2) Secondary reduction: If still intolerant, it can be further reduced to 80mg twice a day.
(3) Termination of treatment: If the 80mg dose is still intolerable, permanent discontinuation of the medication is required.
3. Medication for special populations
(1) Liver dysfunction: Mild injury does not require adjustment, moderate to severe cases require a reduction to 80mg twice daily.
(2) Renal insufficiency: Mild to moderate injuries do not require adjustment, while severe patients require close monitoring.
(3) Pregnancy and lactation: May cause harm to the fetus, contraception should be used during treatment and within one week after discontinuation of medication.
4. Medication precautions
(1) Omission treatment: If there is less than 6 hours before the next administration, it should be skipped and not supplemented or doubled in dosage.
(2) Vomiting treatment: Vomiting after administration does not require supplementation, and the next dose should be taken according to the original plan.
(3) Drug interactions: Avoid combination with strong CYP3A inhibitors/inducers and adjust dosage if necessary.
Disclaimer：《Usage, Dosage, and Medication Guidelines for Selpercatinib》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！