Indications, usage and dosage of quizartinib
Quizartinib is an FLT3 tyrosine kinase inhibitor mainly used to treat specific types of acute myeloid leukemia. Its standard dose needs to be adjusted according to the patient's condition, and attention should be paid to the safety of medication for special populations.
1. Indications
Quetzatinib is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML) adult patients with FLT3-ITD mutations. This drug selectively inhibits FLT3 receptor tyrosine kinase, blocks the tumor cell proliferation signaling pathway, and is suitable for targeted therapy after standard treatment failure.
2. Usage and dosage
(1) Standard dose
The recommended dosage for adult patients is once daily oral administration of 30mg, which should be taken on an empty stomach (1 hour before or 2 hours after meals). Treatment should continue until disease progression or intolerable toxic reactions occur.
(2) Dose adjustment
When QT interval prolongation occurs, administration should be suspended until recovery, and subsequently reduced to 20mg per day. If other grade 3 or above adverse reactions occur, administration should be suspended until recovery to ≤ grade 1, and treatment should be continued at the same or reduced dose.
3. Medication for special populations
(1) Liver dysfunction
Mild liver dysfunction does not require dose adjustment, and patients with moderate to severe liver dysfunction should use it with caution. It is recommended to start with lower doses and closely monitor.
(2) Renal insufficiency
Mild to moderate renal impairment does not require dose adjustment, and patients with severe renal impairment have limited data and should be used with caution under the guidance of a doctor.
(3) Elderly patients
Patients aged 65 and above do not need to adjust the starting dose, but due to their potential sensitivity to medication, it is necessary to strengthen adverse reaction monitoring.
(4) Pregnancy and lactation
Having embryonic fetal toxicity, women of childbearing age need to take effective contraceptive measures. Breastfeeding women should stop breastfeeding or medication.
Disclaimer：《Indications, usage and dosage of quizartinib》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！