Side effects and relief methods of quizartinib
Quizartinib, as an FLT3 inhibitor, commonly has side effects including hematological toxicity, prolonged cardiac QT interval, and gastrointestinal reactions, which need to be alleviated through regular monitoring and targeted measures. The following provides a detailed explanation from three aspects: classification of side effects, coping strategies, and special precautions.
1. Common side effects and mitigation measures
(1) Hematological toxicity: manifested as neutropenia, anemia, etc. It is recommended to monitor blood routine every week, suspend medication when grade 3 or above bone marrow suppression occurs, and provide G-CSF or transfusion support if necessary.
(2) QT interval prolongation: ECG examination is required before medication, and blood potassium/magnesium levels should be monitored during treatment. Avoid using other QT prolonging drugs in combination and seek medical attention immediately if dizziness/palpitations occur.
(3) Gastrointestinal reactions: Nausea and vomiting can be prevented by using antiemetic drugs. Electrolytes should be replenished during diarrhea, and in severe cases, dosage should be reduced.
2 serious side effects that require urgent treatment
(1) Arrhythmia: Sudden chest pain, fainting, or difficulty breathing require immediate discontinuation of medication and electrocardiographic monitoring, intravenous potassium/magnesium supplementation to correct electrolyte imbalances.
(2) Pancreatitis: amylase is detected during persistent upper abdominal pain accompanied by vomiting, and medication is permanently discontinued upon diagnosis.
(3) Allergic reactions: Hormone therapy is required when the rash progresses to Stevens Johnson syndrome.
3 Precautions for Special Groups
(1) Liver dysfunction: Children Pugh B/C grade patients need to reduce their dosage by 50% and regularly monitor transaminase levels.
(2) Patients of childbearing age: Effective contraception is required during treatment and 6 months after discontinuation of medication, as male patients may affect sperm production.
(3) Elderly patients are more prone to QT prolongation, and it is recommended to reduce the starting dose by 25%.
4 Daily management suggestions
(1) Dietary adjustment: Avoid grapefruit and high-fat diet, eat in small portions to reduce nausea.
(2) Infection prevention: Strengthen hand hygiene and avoid contact with patients with respiratory infections.
(3) Sunscreen measures: Use SPF30+sunscreen to prevent photosensitive rash.
Disclaimer：《Side effects and relief methods of quizartinib》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！