What does Axitinib treat? How is the effect?
Axitinib is a tyrosine kinase inhibitor of vascular endothelial growth factor receptor (VEGFR), mainly used for second-line treatment of advanced renal cell carcinoma. Its efficacy is reflected in prolonging progression free survival and objective response rate, but it needs to be evaluated based on the individual patient's situation.
1. Indications for treatment
(1) Advanced renal cell carcinoma: suitable for adult patients who have previously failed a systemic treatment (such as sunitinib or cytokine therapy) as a second-line targeted therapy.
(2) Metastatic clear cell carcinoma: targeting specific pathological types of renal cancer patients, especially those with strong dependence on the VEGFR signaling pathway, the effect is more significant.
2. Evaluation of treatment efficacy
(1) Progression free survival: Clinical trials have shown that the median progression free survival can reach 6.7-8.3 months, which is significantly longer than the placebo group.
(2) Objective response rate: The objective response rate of monotherapy is about 19% -44%, and some patients can achieve tumor shrinkage of more than 30%.
3 mechanisms of action
(1) Targeted inhibition: selectively blocking VEGFR-1/2/3, inhibiting tumor angiogenesis, and cutting off tumor blood supply.
(2) Synergistic effect: When used in combination with immune checkpoint inhibitors, it may enhance anti-tumor immune response and is currently in the clinical research stage.
4 Precautions for use
(1) Differences in therapeutic efficacy: The therapeutic effect is greatly influenced by the patient's physical condition, past treatment response, and drug tolerance.
(2) Drug resistance management: Drug resistance may occur after about 6-15 months, and treatment plans need to be adjusted in a timely manner through imaging evaluation.
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