Adagrasib is usually consumed for several months
The duration of medication for Adagrasib needs to be dynamically adjusted according to individual patient conditions. Clinical data shows a median treatment duration of 8.2 months, and the actual medication cycle depends on tumor response and drug tolerance, usually lasting until disease progression or uncontrollable toxicity occurs.
1 standard treatment cycle
(1) Basic treatment course: In clinical trials, patients continued medication for an average of 8.2 months, ranging from 1 month to over 20 months.
(2) Evaluation Node: The first imaging evaluation is usually conducted 6-8 weeks after medication, and subsequent follow-up examinations are conducted every 2-3 months to confirm efficacy.
2 influencing factors
(1) Tumor response: Patients who achieve partial remission or disease stability can take long-term medication, with a median progression free survival of about 6.5 months.
(2) Side effect management: About 40% of patients need to reduce or suspend medication due to adverse reactions, which may affect the actual duration of medication.
3 Special Adjustments
(1) Liver injury patients: Child Pugh B grade should be reduced to 600mg/day, which may prolong the adjustment period.
(2) Elderly patients: Those aged 75 and above need to strengthen monitoring, but there is no need to shorten the course of treatment solely based on age.
4 Discontinuation criteria
(1) Absolute indication: Confirmation of disease progression or occurrence of irreversible toxicity (such as grade 4 liver injury).
(2) Relative indication: QT interval prolongation of grade 2 or above, or persistent non hematological toxicity of grade 3 without relief.
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