How to eat elacestrant
The standard method of taking elacestrant is once daily oral administration of 345mg (four tablets of 86mg each), which should be swallowed whole and continued until disease progression or intolerable toxicity occurs. Special attention should be paid to the handling of missed doses, dosage adjustments, and medication contraindications for special populations.
1. Routine administration method
(1) Dosage: Take 345mg orally at a fixed time daily, equivalent to four 86mg tablets.
(2) Usage: Swallow the whole tablet, it can be taken with food or taken alone, and cannot be broken or chewed.
2. Principles for handling missed services
(1) Exceeding 6 hours of missed dose: skip this dose and continue taking according to the original plan the next day.
(2) Vomiting after taking medication: considered as missed dose, the same dose should be taken on the same day.
3 Dose Adjustment Guidelines
(1) First dose reduction: 258mg (86mg for three tablets), suitable for moderate liver damage or grade 2 toxicity.
(2) Secondary dose reduction: 172mg (two tablets of 86mg), used for recurrent grade 3 toxicity.
(3) Permanent discontinuation of treatment: Discontinue treatment when grade 4 toxicity recurs or cannot be tolerated.
4 Special precautions
(1) Liver dysfunction: Moderate to severe patients need to reduce dosage or discontinue use, while mild cases do not require adjustment.
(2) Fertility patients: Strict contraception is required during treatment and one week after discontinuation of medication.
(3) Breastfeeding taboos: Breastfeeding is prohibited during the medication period and one week after the last dose.
Disclaimer：《How to eat elacestrant》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！