What does Lenvatinib treat
Lenvatinib is a multi-target tyrosine kinase inhibitor mainly used to treat malignant tumors such as thyroid cancer, hepatocellular carcinoma, and renal cell carcinoma, exerting anti-tumor effects by inhibiting angiogenesis and tumor growth.
1. Main indications
(1) Differentiated thyroid cancer: used for locally recurrent or metastatic cases that are difficult to treat with radioactive iodine.
(2) Hepatocellular carcinoma: first-line treatment for unresectable advanced liver cancer patients.
(3) Renal cell carcinoma: Combination therapy with everolimus for advanced cases that have previously received anti angiogenic therapy.
2. Mechanism of action
(1) Target inhibition: Selective inhibition of receptors such as VEGFR1-3, FGFR1-4, PDGFR α, RET, and KIT.
(2) Anti angiogenesis: Blocking the VEGF signaling pathway and reducing tumor angiogenesis.
(3) Direct anti-tumor effect: By inhibiting pathways such as FGFR, it hinders tumor cell proliferation and metastasis.
3 Clinical Advantages
(1) Liver cancer efficacy: In REFELECT studies, it showed an objective response rate superior to sorafenib.
(2) Combination therapy: Combined with PD-1 inhibitors can enhance the efficacy of immunotherapy.
(3) Convenient administration: once daily oral administration, high patient compliance.
Disclaimer：《What does Lenvatinib treat》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！