Cabozantinib is usually taken for several months
卡博替尼(Cabozantinib)的用药时长取决于适应症类型和个体反应，通常需持续服用直至疾病进展或出现不可耐受毒性，仅在与纳武单抗联合治疗肾细胞癌时明确限定最长24个月。
1 单药治疗的持续时间
(1)甲状腺髓样癌：每日140mg持续口服，无固定用药月份限制。
(2)肾细胞癌/肝细胞癌：每日60mg连续服用，中位无进展生存期约7-11个月。
2 联合治疗的时限规定
(1)与纳武单抗联用：每日40mg联合静脉给药，明确最长持续2年(24个月)。
(2)联合方案需每2-4周评估疗效，可能提前终止治疗。
3 影响用药时长的关键因素
(1)疾病进展速度：快速进展者可能仅用药3-6个月。
(2)毒性反应：约20%患者因不良反应在6个月内减量或停药。
(3)肝功能状态：中度损害者需减量并缩短用药周期。
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