Taboo populations, taboo foods, and restrictive conditions for Bayer's version of Dienogest in Germany
Dienogest, as a highly effective progestogen preparation, should be strictly followed in terms of contraindications, dietary restrictions, and usage limitations. The following provides a detailed explanation from three aspects: taboo groups, taboo foods, and special restrictions.
1. Taboo population
(1) Pregnant women: May interfere with fetal development, pregnancy should be ruled out before medication.
(2) Breastfeeding women: Medications can be secreted into breast milk, and should not be used during lactation.
(3) Severe liver function impairment: Not recommended for Child Pugh C patients.
(4) History of thrombosis: Patients with deep vein thrombosis, pulmonary embolism, etc. are prohibited from using it.
(5) Hormone dependent tumors: such as breast cancer and endometrial cancer patients are forbidden.
2. Forbidden foods
(1) Grapefruit and its products: may inhibit CYP3A4 enzyme and increase blood drug concentration.
(2) St. John's wort: induces CYP3A4 enzyme and reduces drug efficacy.
(3) Alcohol: may increase the burden on liver function, it is recommended to limit intake.
3. Restrictive conditions
(1) Cardiovascular risk: Patients with hypertension need to regularly monitor their blood pressure.
(2) Metabolic impact: diabetes patients need to strengthen blood glucose monitoring.
(3) Fertility: It is recommended to wait for 3 months after discontinuing medication before preparing for pregnancy.
(4) Special examination: During medication, thyroid function test results may be affected.
(5) Preoperative discontinuation: Medication should be discontinued 4 weeks before elective surgery to reduce the risk of thrombosis.
Disclaimer：《Taboo populations, taboo foods, and restrictive conditions for Bayer's version of Dienogest in Germany》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！