What are the contraindications for Trabectedin? Do you need to eat for a long time?
The contraindications of Trabectedin mainly involve specific physiological states, drug allergies, and severe organ dysfunction, which must be strictly followed to avoid serious adverse reactions.
1. Allergy related contraindications
(1) It is contraindicated for patients with a history of hypersensitivity reactions to Qubetidine or any ingredients in the formulation, as it may cause severe allergic reactions.
2. Taboos for special physiological states
(1) Pregnancy period: Based on animal studies showing embryotoxicity, pregnant women are prohibited from using contraception. Women of childbearing age should use contraception during treatment and for 3 months after discontinuation.
(2) Breastfeeding period: Medications may be secreted through breast milk, and lactating women should discontinue medication or breastfeeding.
3. Contraindications for organ dysfunction
(1) Liver function impairment: It is contraindicated for patients with severe liver injury (Child Pugh C grade), and dosage adjustment is necessary for moderate to mild cases.
(2) Renal dysfunction: End stage renal disease (CrCl<15mL/min) or dialysis patients should not use it.
4. Taboos related to comorbidities
(1) Active infection: Patients with uncontrolled severe infections are prohibited from using the medication as it may exacerbate immune suppression.
(2) Bone marrow suppression: baseline neutrophils<1.5 × 10 ⁹/L or platelets<100 × 10 ⁹/L are contraindicated.
5. Taboos of drug interactions
(1) Strong CYP3A4 inhibitors: Combination use of clarithromycin and other drugs is prohibited as it may cause toxic accumulation.
(2) Live vaccine: Avoid vaccination during treatment as it may increase the risk of infection.
6. Standard dosing regimen
(1) The recommended dosage is 1.5mg/m ², administered via 24-hour intravenous infusion, with a treatment cycle of every 3 weeks.
(2) Continuous medication is required until disease progression or intolerable toxicity occurs, and the median number of treatment cycles varies depending on the type of tumor.
7. Adjustment factors for treatment course
(1) Hematological toxicity: When grade 3-4 neutropenia occurs, delayed administration or reduction to 1.2mg/m ² is required.
(2) When liver function is abnormal: bilirubin>ULN or transaminase elevation>2.5 times ULN, medication should be suspended and reduced after recovery.
Disclaimer：《What are the contraindications for Trabectedin? Do you need to eat for a long time?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！