How many courses of Alpelisib are usually administered? Do you need to eat for a long time?
The treatment design of Alpelisib is not a traditional fixed cycle model, but based on the principle of continuous treatment, requiring long-term medication until disease progression or intolerable toxicity occurs.
1. Basic treatment principles
(1) It is recommended to use a daily continuous administration regimen of 300mg, with no predetermined treatment period, and should be taken at a fixed time with meals.
(2) The SOLAR-1 study showed that the median duration of treatment was about 8 months, and the actual course of treatment varied significantly among individuals.
2. Adjustment criteria for treatment course
(1) Disease progression: Terminate the current course of treatment when imaging confirms tumor deterioration.
(2) Toxic reactions: Grade 4 hyperglycemia, grade 3 or above pneumonia, etc. require permanent discontinuation of medication, and grade 2-3 adverse reactions can be reduced and maintained.
3. Management of treatment courses for special populations
(1) Patients with diabetes: blood glucose monitoring should be strengthened. Fasting blood glucose should be measured weekly in the first two weeks, which may affect the continuity of treatment.
(2) Elderly patients: People aged 75 and above need to be closely evaluated for high blood sugar risk and adjust the pace of treatment if necessary.
4. Combination therapy course
When used in combination with Fluvistran, the latter is administered at a monthly cycle of 500mg, while Apilis still maintains a daily continuous medication pattern.
5. Discontinuation criteria
(1) Disease progression: Treatment should be terminated when imaging or clinical evaluation confirms tumor deterioration.
(2) Serious toxic reactions: including grade 4 hyperglycemia, grade 3 or above pneumonia, severe skin reactions, etc. requiring permanent discontinuation of medication.
6. Special case handling
(1) Dose adjustment: In case of grade 2-3 adverse reactions, the dosage can be temporarily reduced to 250mg or 200mg once daily.
(2) Interruption of treatment: If the missed dose exceeds 9 hours, skip the daily dose and restore the original dose the next day after vomiting.
Disclaimer：《How many courses of Alpelisib are usually administered? Do you need to eat for a long time?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！