Should Alpelisib be eaten before and after meals? What is the storage environment?
Alpelisib needs to be taken with meals to optimize drug absorption. If missed, it should be taken according to the time window, and there is no need to take it again after vomiting. The storage of Alpelisib requires strict temperature control and maintaining the integrity of the original packaging to ensure drug stability.
1. Regular administration time
The recommended dose of aprilase is 300mg orally once daily (2 150mg film coated tablets), which must be taken with meals to increase bioavailability. Fixed daily medication time, the whole tablet should not be chewed or crushed to ensure stable blood drug concentration.
2. Leakage Handling Plan
(1) Within 9 hours of missed dose: immediately supplement the current dose with meals to maintain stable drug exposure.
(2) Exceeding 9 hours: skip the daily dose and continue taking the medication according to the original plan the next day. Double dose supplementation is prohibited.
3. Coping with postprandial vomiting
Vomiting after taking medication does not require supplementation to avoid the risk of overdose caused by repeated administration. The next day, the regular dosage treatment will continue as scheduled, during which blood glucose and other indicators need to be monitored.
4. Special dietary requirements
(1) Standard meal: Should be taken with a complete meal (not snacks), high-fat diet may affect absorption rate.
(2) Dosage adjustment: If the dosage needs to be reduced to 200mg/day, it still needs to be accompanied by meals, but attention should be paid to the weakening of food effects at low doses.
5. Temperature control requirements
(1) The standard storage temperature is 20 ° C to 25 ° C (68 ° F to 77 ° F), which meets most indoor environmental conditions.
(2) The allowable short-term temperature fluctuation range is 15 ° C to 30 ° C (59 ° F to 86 ° F), suitable for transportation or temporary transfer scenarios.
6. Packaging Management Standards
(1) It must be stored in the original sealed container to prevent moisture from coming into contact with air and causing drug degradation.
(2) If the bottle mouth seal is found to be damaged or missing, it should be immediately stopped from use to avoid contamination of the medicine.
7. Special precautions
(1) Avoid placing drugs in areas with high temperature and humidity fluctuations such as bathrooms and kitchens, and keep them away from direct light sources.
(2) It is recommended to use insulated bags to maintain temperature stability during travel, and special monitoring of the storage environment is necessary under extreme weather conditions.
Disclaimer：《Should Alpelisib be eaten before and after meals? What is the storage environment?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！