Stiripentol contraindicated population: Notice for severe liver and kidney dysfunction, allergy sufferers
Situximab is contraindicated for individuals with severe liver and kidney dysfunction and a clear history of allergies, and for those with moderate to mild liver function impairment, reduced monitoring is required. Before medication, a comprehensive assessment of liver and kidney function and allergy history must be conducted to ensure safety.
1、 Severe liver dysfunction patients
1.1 Definition
Refers to Child Pugh C grade decompensated cirrhosis, or ALT/AST>5 × ULN with significantly elevated bilirubin levels.
1.2 Prohibition Basis
Sitriptylol is widely metabolized in the liver, and severe liver damage can lead to drug accumulation, increased liver toxicity, and central inhibitory risk.
1.3 Clinical recommendations
Absolutely prohibited. Patients of this type should not initiate treatment with sitagliptin.
Mild to moderate liver damage (Child Pugh A/B) patients should reduce their dosage and monitor liver function every 2-4 weeks.
2、 Severe renal insufficiency patients
2.1 Definition
Refers to end-stage renal disease with creatinine clearance rate (CrCl)<30mL/min or undergoing dialysis treatment.
2.2 Prohibition Basis
When renal function is severely impaired, the clearance of drugs and their metabolites slows down, increasing the risk of cumulative toxicity.
2.3 Clinical recommendations
Not recommended for use. If necessary, adjust the dosage under specialized guidance and monitor kidney function and electrolytes weekly.
3、 Individuals allergic to any ingredient of this product
3.1 Identification points
Individuals known to be allergic to sitagliptin or its excipients (such as lactose, starch, magnesium stearate, etc.).
3.2 Allergic Symptoms
May present with rash, urticaria, facial edema, difficulty breathing, or a history of anaphylactic shock.
3.3 Handling Principles
Absolutely prohibited and should be marked on the first page of the medical record.
If there is a suspected allergic reaction after medication, the medication should be stopped immediately and emergency treatment should be taken.
Disclaimer：《Stiripentol contraindicated population: Notice for severe liver and kidney dysfunction, allergy sufferers》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！