Finerenone: Usage, Dosage, Renal Function Monitoring, and Precautions
Finarenone is a new type of non steroidal mineralocorticoid receptor antagonist, which is mainly used to treat type 2 diabetes related chronic kidney disease. The following provides a detailed explanation from three aspects: usage, dosage, renal function monitoring, and precautions. The content is strictly organized according to the drug specifications.
1. Usage and dosage
(1) Standard dose: The initial dose is 10mg or 20mg orally once daily, adjusted according to eGFR and blood potassium levels.
(2) Dose adjustment: 20mg can be used when eGFR ≥ 60mL/min/1.73m ²; 10mg is recommended when eGFR 25-60mL/min/1.73m ²; eGFR<25mL/min/1.73m ² is prohibited.
2. Renal function monitoring
(1) Baseline assessment: eGFR and blood potassium levels must be tested before medication.
(2) Regular monitoring: Renal function and blood potassium should be rechecked after the 4th and 12th week of treatment and dose adjustment, and monitored every 3-6 months thereafter.
3 Precautions
(1) Contraindications: Not recommended for patients with severe liver dysfunction (Child Pugh C grade), adrenal insufficiency, and hyperkalemia (>5.0 mmol/L).
(2) Drug interactions: Avoid using potent CYP3A4 inhibitors or inducers in combination, and strengthen blood potassium monitoring when used in combination with ACEI/ARB.
(3) Special populations: contraindicated during pregnancy, weighing the pros and cons during lactation, elderly people do not need to adjust dosage but need to strengthen monitoring.
Disclaimer：《Finerenone: Usage, Dosage, Renal Function Monitoring, and Precautions》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！