What adverse reactions may occur during the use of celecoxib?
As a selective COX-2 inhibitor, the adverse reactions of celecoxib mainly involve the digestive system, cardiovascular system, and allergic reactions. The following provides a detailed explanation from three dimensions: common adverse reactions, serious adverse reactions, and risks for special populations.
1. Digestive system reactions
(1) Upper abdominal pain: The incidence rate is about 12%, usually mild to moderate.
(2) Diarrhea: Commonly seen in the early stages of medication, most of which can be relieved on their own.
(3) Digestive ulcer: The incidence rate of long-term use in patients is about 1.5%.
2. Cardiovascular system risks
(1) Elevated blood pressure: an average increase of 3-5 mmHg, hypertensive patients need to be closely monitored.
(2) Edema: The incidence rate is about 2.1%, which is positively correlated with the dosage.
(3) Risk of myocardial infarction: Long term high-dose use may increase the risk of cardiovascular events.
3. Allergic reactions
(1) Skin reactions: including rash (4.5%), urticaria, etc.
(2) Sulfonamide allergy: The cross allergy rate of sulfonamide drug allergy sufferers is about 10%.
(3) Vascular edema: rare but requires immediate discontinuation of medication.
4. Serious adverse reactions
(1) Gastrointestinal bleeding: manifested as vomiting blood or black stool, with a higher risk in elderly patients.
(2) Liver injury: ALT may increase to more than three times the upper limit of normal.
(3) Renal dysfunction: Especially for patients with dehydration or pre-existing kidney disease, caution should be exercised.
5. Precautions for special populations
(1) Cardiovascular disease patients: It is necessary to evaluate the benefit risk ratio before use.
(2) Patients with renal insufficiency: Do not use when creatinine clearance rate is less than 30ml/min.
(3) Pregnancy: Use in late pregnancy may lead to premature closure of the fetal ductus arteriosus.
Disclaimer：《What adverse reactions may occur during the use of celecoxib?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！