What side effects may occur during the use of the Swiss Roche version of Cobimetinib?
Multiple systemic side effects may occur during treatment with Cobimetinib, and different response measures should be taken according to the severity.
1 Common Self Relieving Side Effects
(1) Skin reaction: About 50% of patients experience rash and photosensitivity. It is recommended to use SPF50+sunscreen and wear protective clothing.
(2) Gastrointestinal symptoms: Mild diarrhea (<4 times a day) can be treated with oral loperamide, and 5-HT3 receptor antagonists can be used for nausea and vomiting.
(3) Fatigue and fatigue: It is recommended to engage in activities in different time periods, maintain 8 hours of sleep per day, and avoid sudden changes in body position.
Serious side effects requiring medical intervention
(1) Cardiotoxicity: When chest pain, palpitations, or lower limb edema occur, stop taking the medication immediately and test for electrocardiogram and troponin.
(2) Visual impairment: Sudden visual impairment or visual distortion indicates retinal vein occlusion, requiring emergency ophthalmology within 24 hours.
(3) Liver injury: permanent discontinuation of medication when jaundice, clay stool, and ALT levels increase by more than three times, and liver protection treatment if necessary.
3 targeted mitigation plans
(1) Skin care: Apply 1% hydrocortisone ointment to the rash area, soak in iodine for paronychia, and avoid trimming nails too short.
(2) Dietary adjustment: During diarrhea, adopt BRAT diet (banana, rice, apple sauce, toast) and supplement electrolyte solution.
(3) Drug adjustment: Dosage adjustment is required for grade 2 and above side effects, and for grade 3-4 side effects, consideration should be given to suspending or terminating treatment.
4 Special precautions
(1) Bleeding risk: When combined with anticoagulant drugs, nosebleeds and hematuria may occur, and coagulation function needs to be monitored.
(2) Embryotoxicity: Pregnant women should avoid using it, and patients of childbearing age should take effective contraceptive measures during treatment.
(3) Drug interactions: CYP3A4 inhibitors can increase blood drug concentrations, so avoid using potent inhibitors in combination.
Disclaimer：《What side effects may occur during the use of the Swiss Roche version of Cobimetinib?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！