What adverse reactions may occur during the process of taking the Celgene version of Ozanimod from the United States?
As an immune modulator, the adverse reactions of ozanimod involve multiple systems and require different treatment measures based on the severity. The following is a classification of possible adverse reactions caused by the drug and recommendations for response.
1 Common adverse reactions
(1) Increased risk of infection: including upper respiratory tract infections, nasopharyngitis, urinary tract infections, etc., with an incidence rate of about 40% -50%.
(2) Cardiovascular effects: About 5% of patients experience bradycardia, and a 4-hour electrocardiogram needs to be monitored after the first dose.
(3) Abnormal liver function: About 10% of patients experience elevated transaminase levels and require regular liver function testing.
2 Serious Adverse Reactions to Be Cautious of
(1) Opportunistic infection: may cause progressive multifocal leukoencephalopathy (PML) and require monitoring of neurological symptoms.
(2) Macular edema: patients with diabetes are at higher risk, and fundus examination is required before medication.
(3) Elevated blood pressure: About 15% of patients experience elevated blood pressure, and regular monitoring of blood pressure changes is necessary.
3 Digestive system reactions
(1) Nausea and vomiting: The incidence rate is about 20%, usually mild and self relieving.
(2) Abdominal pain and diarrhea: About 10% of patients experience it. It is recommended to adjust the diet structure to alleviate symptoms.
(3) Liver function impairment: manifested as jaundice, fatigue, etc., immediate discontinuation of medication and medical attention are required.
4 Neurological reactions
(1) Headache and dizziness: the most common neurological reaction, with an incidence rate of about 25% -30%.
(2) Peripheral neuropathy: manifested as numbness or tingling in the limbs, requiring neurological evaluation.
(3) Epilepsy seizure: rare but severe, patients with a history of epilepsy should use it with caution.
5 Other system reactions
(1) Respiratory system: Symptoms such as coughing and difficulty breathing may occur.
(2) Skin reactions: including allergic reactions such as rash and itching, and medication should be discontinued in severe cases.
(3) Hematological system: Decreased lymphocytes are common and require regular monitoring of blood routine.
Disclaimer：《What adverse reactions may occur during the process of taking the Celgene version of Ozanimod from the United States?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！