What is the therapeutic effect of the French Sanofi version of Sabril?
Sabril is a medication used to treat infantile spasms and refractory complex partial epilepsy, with its efficacy mainly reflected in reducing the frequency of epileptic seizures. The following provides a detailed explanation of its therapeutic effect from the aspects of indications, clinical data, and use in special populations.
Overview of the therapeutic effect of Xibaoning
(1) Infantile spasms
Xibaoning has shown significant therapeutic effects on infantile spasms, effectively reducing the frequency of spasms. Clinical trials have shown that approximately 40% -60% of pediatric patients experience complete cessation of spasms after medication, and some patients experience abnormal improvement in their electroencephalography.
(2) Intractable epilepsy
For complex partial seizures that are ineffective with other antiepileptic drugs, Xibaoning can reduce seizure frequency by more than 50% in approximately 30% -40% of adult patients. The therapeutic effect usually appears within 4 weeks of medication and needs to be continuously evaluated.
Clinical research data
(3) Long term efficacy observation
About 50% of patients with infantile spasms who have been taking medication continuously for more than one year maintain a spastic free state. However, the recurrence rate is relatively high after discontinuing the medication, and it is necessary to gradually reduce the dosage and closely monitor.
(4) Compared with other drugs
Compared to traditional therapies such as ACTH, Xibaoning has a faster onset of action and a different spectrum of side effects, but the risk of visual impairment needs to be closely monitored. Combination therapy can improve the response rate of some refractory cases.
Precautions for use
(5) Efficacy evaluation cycle
It is recommended to evaluate changes in seizure frequency every 2-4 weeks after medication. If ineffective after 3-6 months, alternative options should be considered. There is a significant correlation between efficacy and dosage, and the titration protocol should be strictly followed.
(6) Special population response
Individuals with abnormal liver function may affect drug metabolism and require dosage adjustment. The therapeutic effect of elderly patients is comparable to that of adults, but visual monitoring needs to be strengthened.
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