Is there anything to pay attention to when taking the French Pierre Fabre version of Neratinib in terms of diet?
When taking Neratinib, attention should be paid to the impact of diet on drug absorption and adverse reactions. Reasonable dietary adjustments can improve tolerance. The following provides a detailed explanation of precautions regarding taboo foods, recommended diets, and time management.
1 Foods to Avoid
(1) Grapefruits and their products: containing CYP3A4 inhibitors, may increase blood drug concentrations, increase the risk of diarrhea and liver toxicity.
(2) High fat diet: Avoid taking with fried foods as it may delay drug absorption and reduce bioavailability.
(3) Alcohol: It increases the metabolic burden on the liver and may exacerbate elevated transaminase levels and gastrointestinal irritation.
2 Recommended dietary combinations
(1) Mild food: When taking medicine, it is paired with low fiber foods such as oatmeal Congee and Mantou to reduce gastrointestinal irritation.
(2) Fluid replacement options: Drink at least 2L of water daily, and supplement with oral rehydration salts containing electrolytes when experiencing diarrhea.
(3) Protein intake: Increase easily digestible proteins such as eggs and fish in moderation to maintain a nutritious state.
3. Medication schedule
(1) Best Time: It is recommended to take it 30 minutes after breakfast to buffer gastrointestinal irritation with food.
(2) Interval requirement: There should be a 2-hour interval between acid suppressants (such as omeprazole) to avoid affecting drug dissolution.
(3) Dairy product restrictions: Avoid high calcium foods such as milk for 1 hour before and after taking medication to prevent the formation of insoluble complexes.
4. Handling of Special Situations
(1) When experiencing severe diarrhea: adopt a BRAT diet (bananas, rice, apple puree, toast) and avoid spicy and high sugar foods.
(2) Abnormal liver function: Strictly follow a low-fat diet, limit the intake of animal organs and nuts, and reduce the burden on the liver.
(3) Oral ulcers: Choose room temperature liquid or soft foods to avoid acidic (such as citrus) and hard foods that can irritate the wound.
Disclaimer：《Is there anything to pay attention to when taking the French Pierre Fabre version of Neratinib in terms of diet?》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！