Taboo People, Taboo Foods, and Restrictions of Mitotane in Laos' Lusius Version
The taboo population, taboo foods, and restrictive conditions of Mitotane must be strictly followed to ensure the safety and effectiveness of the medication.
1 Taboo population
(1) Pregnant women: Mitotan has clear embryotoxicity and is absolutely contraindicated for pregnant women. Women of childbearing age need to confirm that they are not pregnant before treatment, and effective contraceptive measures should be taken during the treatment period and within 3 months after discontinuation of medication.
(2) Patients with severe liver function impairment: Mitotan should be contraindicated, while those with mild to moderate liver function impairment should reduce dosage by 25% -50% and closely monitor liver function indicators.
(3) For those allergic to metoclopramide: Do not use this medication. If an allergic reaction occurs, stop taking the medication immediately and seek medical treatment.
2 Forbidden Foods
(1) Grapefruit and its products: contain potent CYP3A4 inhibitors, which may significantly increase the blood concentration and toxicity risk of mitoxan. It should be completely avoided during treatment.
(2) High fat diet: may promote the absorption of mitoxan, leading to fluctuations in blood drug concentration. It is recommended to maintain a stable fat content in the diet.
(3) Alcoholic beverages: may exacerbate liver toxicity and central nervous system inhibition, and should be avoided during treatment.
3 Restrictions
(1) Blood drug concentration monitoring: Regular monitoring is required during treatment, with a target range of 14-20mg/L, and the dosage should be adjusted based on the results.
(2) Liver function monitoring: ALT/AST should be monitored monthly, and medication should be suspended when the ULN increases by more than 3 times.
(3) Neurological monitoring: Elderly patients should reduce their initial dose by 25% and strengthen monitoring of symptoms such as drowsiness and ataxia.
4 Storage precautions
(1) Avoid direct sunlight or strong light exposure. It is recommended to store in the original opaque packaging box.
(2) Moisture proof treatment: Keep the environment dry and do not place drugs in damp places such as bathrooms. If the packaging contains desiccants, they should be kept in the container.
(3) Child safety: Store at a height out of reach of children or in a locked cabinet to prevent the risk of accidental ingestion.
Disclaimer：《Taboo People, Taboo Foods, and Restrictions of Mitotane in Laos' Lusius Version》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！