The efficacy and drug interactions of Japanese Yakult version Mitotane
Mitotane is a cytotoxic drug used to treat adrenal cortex cancer, and its mechanism of action and drug interactions require special attention. The following provides a detailed explanation from two aspects: treatment efficacy and drug interactions.
The effect of 1 meter of atropine
Mitotan works by selectively disrupting mitochondrial function in adrenal cortex cells, inhibiting cortisol synthesis and inducing tumor cell apoptosis. Clinical data shows that the objective response rate is about 30% -40%, and the median progression free survival is about 5-6 months.
2 drug interactions
2.1 Liver drug enzyme related interactions
Mitotan is a strong inducer of CYP3A4, which may reduce the blood drug concentration of drugs metabolized by this enzyme. Special attention should be paid to the following interactions:
(1) CYP3A4 substrates such as midazolam and simvastatin may have reduced efficacy. (2) Hormonal drugs: may reduce the effectiveness of contraceptive pills, it is recommended to use non hormonal contraceptive measures.
2.2 Specific drug interactions
(1) Anticoagulants: may increase the risk of bleeding and require close monitoring of INR values. (2) Central nervous system inhibitors: may enhance sedative effects, caution should be exercised when combined.
2.3 Food Interactions
A high-fat diet may increase the absorption of mitoxan, and it is recommended to take it on an empty stomach at fixed times to maintain stable blood drug concentrations. Grapefruit juice may interfere with metabolism and should be avoided from being consumed simultaneously.
3 Precautions for use
Regular monitoring of blood drug concentration is required during treatment, with a target range of 14-20mg/L. At the same time, adrenal function, liver function, and neurological symptoms should be monitored, and the dosage should be adjusted in a timely manner.
Disclaimer：《The efficacy and drug interactions of Japanese Yakult version Mitotane》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！