What is the therapeutic effect of the German neuropharm version of Nicergoline? Is there anything to pay attention to when patients stop taking medication?
The therapeutic effect of Nicergoline is mainly reflected in the improvement of cerebral blood vessels and cognitive function enhancement. Discontinuation of the drug should be gradually reduced to avoid rebound effects. The following are specific treatment effects and precautions for discontinuing medication:
1. Treatment effect
(1) Cerebrovascular improvement: can increase cerebral blood flow by 20-30%, especially suitable for patients with chronic cerebral ischemia.
(2) Cognitive function: Clinical trials have shown an average improvement of 2-3 points in MMSE scores, which is effective for mild cognitive impairment.
(3) Dizziness relief: 75% of patients showed significant reduction in dizziness symptoms within 2 weeks of medication.
(4) Tinnitus improvement: After 8 weeks of continuous medication, 50% of patients experienced a reduction in tinnitus intensity of ≥ 50%.
2 Precautions for discontinuation of medication
2.1 Conventional discontinuation plan
(1) Short term medication (<4 weeks): can be stopped directly.
(2) Long term medication: 50% reduction is required every 3 days, with a total reduction period of no less than 2 weeks.
2.2 Discontinuation of medication for special populations
(1) Elderly patients: The reduction rate should be extended to 25% per week to prevent cerebral vasospasm.
(2) Liver dysfunction: Children Pugh B patients need to monitor ALT weekly during drug discontinuation.
2.3 Medication discontinuation monitoring
(1) Blood pressure monitoring: Measure blood pressure in a supine position daily for 7 days after discontinuing medication.
(2) Symptom rebound: About 15% of patients experience headache rebound, which can be relieved with acetaminophen.
2.4 Contraindications for discontinuation of medication
(1) Sudden discontinuation of medication is prohibited within 3 months of the onset of acute cerebral infarction.
(2) When using antihypertensive drugs in combination, it is necessary to adjust the dosage of antihypertensive drugs first and gradually stop using nifedipine.
Follow up after discontinuation of medication
(1) It is recommended to have a follow-up cerebral blood flow chart and cognitive assessment one month after discontinuing the medication.
(2) If symptoms recur, it is necessary to wait at least 4 weeks before resuming treatment.
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