Usage, dosage, and special population medication of Japanese Tanabe Mitsubishi version of Nicergoline
The usage and dosage of Nicergoline should be adjusted according to the indications, and special attention should be paid to cardiovascular risk and metabolic differences when using it for special populations. The following are specific medication guidelines:
1. Conventional usage and dosage
(1) Adult standard dose: 10-20mg taken orally 2-3 times a day, taken after meals to reduce gastrointestinal irritation.
(2) Intravenous administration: limited to acute cases, 5mg diluted and slowly infused, no more than twice a day.
(3) Course adjustment: Chronic disease treatment should last for 8-12 weeks, and the decision to continue will be made after evaluating the efficacy.
2. Medication for special populations
2.1 Pregnant women
(1) Animal studies have shown embryotoxicity and are contraindicated during pregnancy.
(2) Unintended pregnancy should be immediately discontinued and fetal development monitored.
2.2 Breastfeeding women
(1) Medications may be secreted through breast milk and should not be used during lactation.
(2) When medication is necessary, breastfeeding should be stopped and formula feeding should be used instead.
2.3 Patients with liver dysfunction
(1) Half the dose for Child Pugh B patients.
(2) C-grade patients are prohibited from using ALT/AST and need to be monitored weekly.
2.4 Patients with renal insufficiency
(1) The dose is reduced by 30% when GFR30-60ml/min.
(2) GFR<30ml/min is prohibited as it may accumulate and lead to hypotensive crisis.
2.5 Elderly patients
(1) Initial dose of 5mg/day for individuals aged 65 and above, slowly titrate.
(2) It is necessary to monitor changes in blood pressure in the supine position to prevent falls.
3 Medication precautions
(1) Baseline electrocardiogram and liver function test are required before treatment.
(2) Combination use with antihypertensive drugs should be separated by 4 hours to avoid synergistic effects.
(3) Stop taking medication 72 hours before surgery to prevent intraoperative hypotension.
Disclaimer：《Usage, dosage, and special population medication of Japanese Tanabe Mitsubishi version of Nicergoline》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！