Japanese Takeda version Fruquintinib usage, dosage, and special population medication
Fruquintinib is an oral anti-tumor drug, with a standard dosage of 5mg once daily for 3 weeks followed by a 1-week discontinuation. The dosage should be adjusted based on liver function status and adverse reactions.
1. Standard usage and dosage
The recommended dose of Fruquintinib is 5mg once daily, taken continuously for 21 days and stopped for 7 days (28 days per cycle). It should be swallowed whole and can be taken with food or on an empty stomach, but avoid taking with grapefruit juice.
2. Dose adjustment plan
(1) Adjustment of liver dysfunction
Mild liver dysfunction (Child Pugh A grade) patients do not require dose adjustment; For patients with moderate to severe liver dysfunction (Child Pugh B/C grade), it is recommended to reduce the dosage to 4mg or 3mg per day.
(2) Adverse reaction adjustment
If grade 3 hypertension occurs, medication should be suspended until it returns to grade 1 or below, and subsequent treatment should be reduced by one dose level; Grade 4 hand foot syndrome requires permanent discontinuation of medication.
3. Medication for special populations
(1) Pregnant women
Based on animal studies showing teratogenicity, it is contraindicated during pregnancy. Before medication, it is necessary to confirm the pregnancy status, and effective contraceptive measures should be taken during the treatment period and 2 weeks after discontinuation of medication.
(2) Lactating women
There is currently no data on drug concentration in human breast milk. It is recommended to stop breastfeeding during the treatment period and within 2 weeks after the last dose.
(3) Elderly patients
Patients over 65 years old do not need to adjust the starting dose, but monitoring needs to be strengthened as the incidence of adverse reactions may increase.
(4) Child patients
The safety and efficacy of using it for patients under 18 years old have not been established and is not recommended.
4. Absolutely Forbidden Foods
(1) Grapefruit and its products
Grapefruit juice contains potent CYP3A inhibitors, which may increase the blood concentration of fruquintinib by more than twice, increasing the risk of adverse reactions. Beverages containing fresh juice, fruit pulp, and grapefruit ingredients should be avoided.
(2) Seville Orange Products
This variety of orange contains furan coumarin compounds similar to grapefruit, which may interfere with drug metabolism. Avoid consuming derivatives such as jam and citrus tea.
Disclaimer：《Japanese Takeda version Fruquintinib usage, dosage, and special population medication》Edited and sorted by Seagull Pharmacy's editors. Please contact us in time if there is any infringement. In addition, the suggestions for drug usage, dosage and disease mentioned in the article are only for medical staff's reference, and can not be used as any basis for medication！